Skin Health and Disease: Immune, Epithelial and Microbiome Crosstalk

Herrenhausen Palace
Researchers and Professionals

The Keystone Symposia Conference in Hannover (April 9-11, 2019) focusses on mechanisms influencing the epithelial-immune-microbiota crosstalk, opportunities for therapeutic interventions and in-depth cross-disciplinary discussions.

How does the composition of the skin microbiota regulate homeostasis and susceptibility to inflammatory, allergic and neoplastic diseases? (Photo: ©Christoph Burgstedt -
How does the composition of the skin microbiota regulate homeostasis and susceptibility to inflammatory, allergic and neoplastic diseases? (Photo: ©Christoph Burgstedt -

The skin is the largest human organ and the primary interface between the body and the environment. It provides the first line of defense against invading pathogens and trauma via its physical barrier properties but also via active defense mechanisms orchestrated by a coordinated interplay between epithelial and immune cells. Recently, the skin microbiota has emerged as an important third player that critically influences skin homeostasis and inflammation by interacting with epithelial and immune cells. This meeting will aim at illustrating these reciprocal interactions and describing their impact on skin physiology and pathophysiology. A central focus will be to discuss how the composition of the skin microbiota regulates homeostasis and determines susceptibility to inflammatory, allergic and neoplastic diseases of the skin and other epithelial tissues. Emerging concepts on the mechanisms influencing the epithelial-immune-microbiota crosstalk and opportunities for therapeutic interventions will be discussed. The meeting will provide a unique setting for in-depth, cross-disciplinary discussions between basic skin scientists and biologists studying immune responses in other barrier organs, dermatologists, cancer biologists, immunologists, and many researchers from disparate fields who normally do not have opportunities to meet. This meeting will also foster interaction with potential industry partners, who increasingly see the skin as a major focus for gaining insights into immune mechanisms and for development of targeted therapies for patients with chronic inflammatory diseases, allergic diseases and cancer. Finally, the meeting will promote the scientific and professional development of all attendees, with a special emphasis on trainees and early-career scientists.

Keystone Symposia Conference "Skin Health and Disease: Immune, Epithelial and Microbiome Crosstalk"
April 9-11, 2019

Herrenhausen Palace, Hanover, Germany


A detailed program can be found at the conference website:

Conference Topics at a glance 

- Epithelial-Microbiome Interactions in the Skin
- Epithelial-Immune Interactions in the Skin
- Microbiota-Immune Interactions in Skin and other Epithelial Surfaces
- Skin Dysbiosis and Allergic Inflammation
- Epithelial-Microbiota-Immune Interactions in Tumorigenesis and Systemic Diseases
- Emerging Therapeutic Concepts


The conference is jointly organized by Keystone Symposia and the Volkswagen Foundation. The Scientific Organizers are Michel Gilliet (University Hospital of Lausanne), Emma Guttman (Mount Sinai Hospital), Anthony Oro (Stanford University), and Manolis Pasparakis (University of Cologne).

Keystone Symposia on Molecular and Cellular Biology is a 501(c)(3) nonprofit organization headquartered in Silverthorne, Colorado, USA that convenes open, peer-reviewed conferences across a broad range of the life sciences. The mission of Keystone Symposia is to serve as a catalyst for the advancement of biomedical and life sciences by connecting scientists within and across disciplines at conferences and workshops held at venues that create an environment conducive to information exchange, generation of new ideas and acceleration of applications that benefit society. Approximately 50-60 conferences take place each year.


If you want to attend the conference please register through Keystone's website


The conference language is English.

Venue and Public Transport

The conference is held at Herrenhausen Palace, a modern conference center in Hanover, Germany. You can reach the venue by tram: Take the yellow lines 4 or 5 and get off at "Herrenhäuser Gärten".